Professor,
Microbiology
All India Institute of Medical Sciences, Bhubaneswar
Title of the project (Compliance, severity and relapses in case of P. vivax infections): Evaluation and comparison of Malachite Green loop-mediated isothermal amplification (MG-LAMP) and real-time PCR as potential field diagnostic tools for detection of Plasmodium vivax malaria.
Summary:
In 2015, the World Health Organization (WHO) formulated the “Global Technical Strategy for Malaria 2016–2030” with the vision of a world free of malaria by 2030 and in close alignment the National Framework for Malaria Elimination (NFME) 2016–2030 was formulated in India. A special strategy was formulated for P. vivax (Pv) elimination as according to the World Malaria Report 2015, more than 80% of the global Pv burden is contributed by 3 countries including India. Present study will be valuable in formulating an optimal diagnostic test for use as a rapid point-of-care test in the hospital and field settings for detection of P. vivax malaria. Objectives are to compare and evaluate the feasibility of two molecular diagnostic tests i.e., Malachite Green loop-mediated isothermal amplification (MG-LAMP) and real-time PCR, one as a new isothermal test and the other as a molecular test with existing facilities as potential field diagnostic tools for the detection of Plasmodium vivax malaria in febrile patients. Study will enable to determine an optimum field diagnostic tool for the detection of submicroscopic levels of Plasmodium vivax malaria in febrile patients and contribute to the elimination strategy.
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